An interactive website for analytical method comparison and bias estimation Journal Article

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Authors: Bahar, B.; Tuncel, A. F.; Holmes, E. W.; Holmes, D. T.
Article Title: An interactive website for analytical method comparison and bias estimation
Abstract: OBJECTIVES: Regulatory standards mandate laboratories to perform studies to ensure accuracy and reliability of their test results. Method comparison and bias estimation are important components of these studies. DESIGN METHODS: We developed an interactive website for evaluating the relative performance of two analytical methods using R programming language tools. The website can be accessed at https://bahar.shinyapps.io/method_compare/. RESULTS: The site has an easy-to-use interface that allows both copy-pasting and manual entry of data. It also allows selection of a regression model and creation of regression and difference plots. Available regression models include Ordinary Least Squares, Weighted-Ordinary Least Squares, Deming, Weighted-Deming, Passing-Bablok and Passing-Bablok for large datasets. The server processes the data and generates downloadable reports in PDF or HTML format. CONCLUSIONS: Our website provides clinical laboratories a practical way to assess the relative performance of two analytical methods.
Journal Title: Clinical biochemistry
ISSN: 1873-2933; 0009-9120
Publisher: The Canadian Society of Clinical Chemists. Published by Elsevier Inc  
Journal Place: United States
Date Published: 2017
Language: eng
DOI/URL:

S0009-9120(17)30456-3
Notes: LR: 20170828; CI: Copyright (c) 2017; JID: 0133660; OTO: NOTNLM; 2017/05/07 [received]; 2017/07/26 [revised]; 2017/08/15 [accepted]; aheadofprint