A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter? Journal Article

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Authors: Abbott, A. M.; Valente, S. A.; Loftus, L.; Tendulkar, R. D.; Greif, J. M.; Bethke, K. P.; Donnelly, E. D.; Lottich, C.; Ross, D. L.; Friedman, N. B.; Bedi, C. G.; Joh, J. E.; Kelemen, P; Hoefer, R. A.; Kang, S. K.; Ruffer, J.; Police, A.; Fyles, A; Graves, G. M.; Willey, S. C.; Tousimis, E. A.; Small, W; Lyons, J.; Grobmyer, S; Laronga, C
Article Title: A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?
Abstract: BACKGROUND: Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. METHODS: A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages /=70. RESULTS: We evaluated 686 patients (/=70 = 262) who were margin and lymph node negative. Patients /=70 = 262) who were margin and lymph node negative. Patients /= 70. There were 5 (0.73%) breast recurrences (4 in /= 70, p = 0.65) and no axillary recurrences during follow-up. CONCLUSIONS: IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.
Journal Title: American Journal of Surgery
Volume: 214
Issue: 4
ISSN: 1879-1883; 0002-9610
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2017
Start Page: 629
End Page: 633
Language: eng
DOI/URL:

S0002-9610(17)30309-4
Notes: LR: 20170926; CI: Copyright (c) 2017; JID: 0370473; 2017/02/10 [received]; 2017/06/19 [revised]; 2017/06/20 [accepted]; ppublish