SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons Journal Article

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Authors: Plant, L. D.; Zuniga, L.; Araki, D.; Marks, J. D.; Goldstein, S. A.
Article Title: SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons
Abstract: The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels were heterodimeric assemblies of K2P1, a subunit subject to SUMOylation, and the TASK (two-P domain, acid-sensitive K(+)) channel subunits K2P3 or K2P9. The heterodimeric channels comprised the acid-sensitive portion of IKso and mediated its response to halothane. We anticipate that SUMOylation also influences sensation and homeostatic mechanisms in mammals through TASK channels formed with K2P1.
Journal Title: Science signaling
Volume: 5
Issue: 251
ISSN: 1937-9145; 1945-0877
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: ra84
Language: eng
DOI/URL:

10.1126/scisignal.2003431
Notes: LR: 20170220; GR: R01 NS056313/NS/NINDS NIH HHS/United States; GR: R01 NS058505/NS/NINDS NIH HHS/United States; GR: R01NS058505/NS/NINDS NIH HHS/United States; JID: 101465400; 0 (Kcnk1 protein, rat); 0 (Kcnk9 protein, rat); 0 (Multiprotein Complexes); 0 (Nerve Tissue Proteins); 0 (Potassium Channels, Tandem Pore Domain); 0 (potassium channel subfamily K member 3); RWP5GA015D (Potassium); UQT9G45D1P (Halothane); NIHMS538655; OID: NLM: NIHMS538655; OID: NLM: PMC3876883; epublish