Outcomes of 6-month versus 12-month dual antiplatelet therapy after drug-eluting stent implantation: A meta-analysis and meta-regression Journal Article

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Authors: Villablanca, P. A.; Massera, D.; Mathew, V; Bangalore, S; Christia, P.; Perez, I.; Wan, N.; Schulz-Schupke, S.; Briceno, D. F.; Bortnick, A. E.; Garcia, M. J.; Lucariello, R.; Menegus, M.; Pyo, R.; Wiley, J.; Ramakrishna, H
Article Title: Outcomes of 6-month versus 12-month dual antiplatelet therapy after drug-eluting stent implantation: A meta-analysis and meta-regression
Abstract: BACKGROUND: The benefit of 40 was identified, effects were obtained with random models. RESULTS: Nine RCTs were included with total n = 19,224 patients. No significant differences were observed between lt;/=6-month compared with 12-month DAPT in all-cause mortality (OR 0.87; 95% confidence interval (CI): 0.69-1.11), cardiovascular (CV) mortality (OR 0.89; 95% CI: 0.66-1.21), non-CV mortality (OR 0.85; 95% 0.58-1.24), myocardial infarction (OR 1.10; 95% CI: 0.89-1.37), stroke (OR 0.97; 95% CI: 0.67-1.42), stent thrombosis (ST) (OR 1.37; 95% CI: 0.89-2.10), and target vessel revascularization (OR 0.95; 95% CI: 0.77-1.18). No significant difference in major bleeding (OR 0.72; 95% CI: 0.49-1.05) was observed, though the all-bleeding event rate was significantly lower in the lt;/=6-month DAPT group (OR 0.76; 95% CI: 0.59-0.96). In the meta-regression analysis, a significant association between bleeding events and non-CV mortality with 12-month DAPT was found, as well as between ST and mortality in addition to MI with lt;/=6-month DAPT. CONCLUSION: DAPT for lt;/=6 months is associated with similar mortality and ischemic outcomes but less bleeding events compared with 12-month DAPT after PCI with DES.
Journal Title: Medicine
Volume: 95
Issue: 52
ISSN: 1536-5964; 0025-7974
Publisher: Unknown  
Journal Place: United States
Date Published: 2016
Start Page: e5819
Language: eng
DOI/URL:

10.1097/MD.0000000000005819
Notes: LR: 20170110; JID: 2985248R; ppublish