Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine Journal Article

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Authors: Murata, S; Zhang, C; Finch, N.; Zhang, K; Campo, L; Breuer, E. K.
Article Title: Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Administration (USFDA) and the European Commission (EC) approval for use in BRCA-mutated advanced ovarian cancer treatment. The need to identify biomarkers, their interactions in DNA damage repair pathways, and their potential utility in identifying patients who are candidates for PARP inhibitor treatment is well recognized. In this review, we detail many of the biomarkers that have been investigated for their ability to predict both PARP inhibitor sensitivity and resistance in preclinical studies as well as the results of several clinical trials that have tested the safety and efficacy of different PARP inhibitor agents in BRCA and non-BRCA-mutated cancers.
Journal Title: BioMed research international
Volume: 2016
ISSN: 2314-6141
Publisher: Unknown  
Journal Place: United States
Date Published: 2016
Start Page: 2346585
Language: ENG
DOI/URL:

10.1155/2016/2346585
Notes: LR: 20160919; JID: 101600173; 2016/06/09 [received]; 2016/07/28 [accepted]; ppublish