Authors: | Bertoni, A. G.; Kramer, H; Watson, K.; Post, W. S. |
Article Title: | Diabetes and Clinical and Subclinical CVD |
Abstract: | Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC >0; above CAC >400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology. |
Journal Title: | Global heart |
Volume: | 11 |
Issue: | 3 |
ISSN: | 2211-8179 |
Publisher: | World Heart Federation (Geneva). Published by Elsevier B.V |
Journal Place: | England |
Date Published: | 2016 |
Start Page: | 337 |
End Page: | 342 |
Language: | ENG |
DOI/URL: |
S2211-8160(16)30705-0 |
Notes: | LR: 20161016; CI: Copyright (c) 2016; JID: 101584391; 2016/03/14 [received]; 2016/07/19 [revised]; 2016/07/21 [accepted]; ppublish |