Diabetes and Clinical and Subclinical CVD Journal Article

Authors: Bertoni, A. G.; Kramer, H; Watson, K.; Post, W. S.
Article Title: Diabetes and Clinical and Subclinical CVD
Abstract: Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC >0; above CAC >400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.
Journal Title: Global heart
Volume: 11
Issue: 3
ISSN: 2211-8179
Publisher: World Heart Federation (Geneva). Published by Elsevier B.V  
Journal Place: England
Date Published: 2016
Start Page: 337
End Page: 342
Language: ENG
Notes: LR: 20161016; CI: Copyright (c) 2016; JID: 101584391; 2016/03/14 [received]; 2016/07/19 [revised]; 2016/07/21 [accepted]; ppublish