Obesity-related metabolite profiles of black women spanning the epidemiologic transition Journal Article

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Authors: Dugas, L. R.; Chorell, E.; Plange-Rhule, J; Lambert, E. V.; Cao, G; Cooper, R. S.; Layden, B. T.; Scholten, D.; Olsson, T.; Luke, A; Goedecke, J. H.
Article Title: Obesity-related metabolite profiles of black women spanning the epidemiologic transition
Abstract: In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 +/- 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.
Journal Title: Metabolomics : Official journal of the Metabolomic Society
Volume: 12
Issue: 3
ISSN: 1573-3882; 1573-3882
Publisher: Unknown  
Date Published: 2016
Start Page: 45. Epub 2016 Feb 5
Language: ENG
DOI/URL:

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Notes: LR: 20160629; GR: R01 DK080763/DK/NIDDK NIH HHS/United States; JID: 101274889; NIHMS791264; OTO: NOTNLM; PMCR: 2017/03/01 00:00; 2016/02/05 [epublish]; ppublish