Peripheral Retinopathy Associated with Aplastic Anemia Journal Article

Authors: Metelitsina, T. I.; Sheth, V. S.; Patel, S. B.; Grassi, M. A.
Article Title: Peripheral Retinopathy Associated with Aplastic Anemia
Abstract: PURPOSE: To report a case of severe, bilateral, rapidly progressing peripheral retinal nonperfusion associated with underlying aplastic anemia. METHODS: An interventional case report. RESULTS: A 4-year-old girl presented with decreased visual acuity. On clinical examination, she was found to have a RAPD, elevated intraocular pressure, 360 degrees rubeosis, vitreous hemorrhage, severe exudative retinal detachment, and telangiectasia with severe peripheral retinal nonperfusion. Laboratory workup was significant for pancytopenia, and a bone marrow biopsy showed extreme hypocellularity with no malignant cells. The patient was diagnosed with primary aplastic anemia. She developed dramatic progression of retinal nonperfusion in the left eye, as well as in the fellow right eye. This bilateral retinopathy was poorly responsive to aggressive management, which included laser photocoagulation and intravitreal injections of anti-vascular endothelial growth factor medications. CONCLUSION: Asymmetric, bilateral quickly progressing peripheral retinal ischemia, in conjunction with pancytopenia and otherwise negative workup may be related to underlying bone marrow failure and aplastic anemia.
Journal Title: Retinal cases brief reports
ISSN: 1937-1578; 1935-1089
Publisher: Unknown  
Date Published: 2016
Language: ENG
Notes: LR: 20160527; GR: P30 EY001792/EY/NEI NIH HHS/United States; GR: R01 EY023644/EY/NEI NIH HHS/United States; JID: 101298744; aheadofprint