Quality of Life and Sexual Function 2 Years After Vaginal Surgery for Prolapse Journal Article

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Authors: Lukacz, E. S.; Warren, L. K.; Richter, H. E.; Brubaker, L; Barber, M. D.; Norton, P.; Weidner, A. C.; Nguyen, J. N.; Gantz, M. G.
Article Title: Quality of Life and Sexual Function 2 Years After Vaginal Surgery for Prolapse
Abstract: OBJECTIVE: To longitudinally assess the effect of native tissue vaginal apical prolapse repair with anti-incontinence surgery on quality of life, sexual function, and body image between uterosacral and sacrospinous suspensions. METHODS: A planned secondary analysis was performed on 374 women enrolled in a randomized trial of the two types of native tissue repair for apical prolapse. Condition-specific and generic quality of life, sexual function, overall and de novo dyspareunia, and body image were assessed using validated instruments at baseline; 6, 12, and 24 months postoperatively; and changes from baseline were assessed and compared between surgical groups. General linear mixed models were used for comparisons and clinically significant differences were assessed using minimum important differences. RESULTS: Of the women randomized, 82% had outcomes available at 2 years. Overall, clinically and statistically significant improvements in generic and condition-specific quality of life and sexual function were observed after surgery. Dyspareunia rates decreased from 25% to 16% by 24 months with only 3% of all women undergoing treatment. De novo dyspareunia occurred in 5% and 10% by 12 and 24 months, respectively. Body image scores also significantly improved from baseline. There were no clinically meaningful or statistically significant differences between groups for any of these outcomes (all P>.05). CONCLUSION: Native tissue vaginal prolapse surgery results in statistically and clinically significant improvements in quality of life, sexual function, and body image at 24 months with no significant differences between uterosacral and sacrospinous suspensions. One in 10 women experience de novo dyspareunia but few requested treatment. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00597935.
Journal Title: Obstetrics and gynecology
Volume: 127
Issue: 6
ISSN: 1873-233X; 0029-7844
Publisher: Unknown  
Journal Place: United States
Date Published: 2016
Start Page: 1071
End Page: 1079
Language: eng
DOI/URL:

10.1097/AOG.0000000000001442
Notes: LR: 20160525; GR: U10 HD054214/HD/NICHD NIH HHS/United States; JID: 0401101; NIHMS772331; OID: NLM: NIHMS772331 [Available on 06/01/17]; OID: NLM: PMC4879084 [Available on 06/01/17]; PMCR: 2017/06/01 00:00; ppublish