The obese gut microbiome across the epidemiologic transition Journal Article

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Authors: Dugas, L. R.; Fuller, M.; Gilbert, J.; Layden, B. T.
Article Title: The obese gut microbiome across the epidemiologic transition
Abstract: The obesity epidemic has emerged over the past few decades and is thought to be a result of both genetic and environmental factors. A newly identified factor, the gut microbiota, which is a bacterial ecosystem residing within the gastrointestinal tract of humans, has now been implicated in the obesity epidemic. Importantly, this bacterial community is impacted by external environmental factors through a variety of undefined mechanisms. We focus this review on how the external environment may impact the gut microbiota by considering, the host's geographic location 'human geography', and behavioral factors (diet and physical activity). Moreover, we explore the relationship between the gut microbiota and obesity with these external factors. And finally, we highlight here how an epidemiologic model can be utilized to elucidate causal relationships between the gut microbiota and external environment independently and collectively, and how this will help further define this important new factor in the obesity epidemic.
Journal Title: Emerging themes in epidemiology
Volume: 13
ISSN: 1742-7622; 1742-7622
Publisher: Unknown  
Journal Place: England
Date Published: 2016
Start Page: 2
End Page: 015-0044-5. eCollection 2016
Language: eng
DOI/URL:

10.1186/s12982-015-0044-5
Notes: LR: 20160115; JID: 101232986; OID: NLM: PMC4710045; OTO: NOTNLM; 2016 [ecollection]; 2015/06/20 [received]; 2015/12/15 [accepted]; 2016/01/11 [epublish]; epublish