Transplanting Kidneys from Deceased Donors With Severe Acute Kidney Injury Journal Article

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Authors: Heilman, R. L.; Smith, M. L.; Kurian, S. M.; Huskey, J.; Batra, R. K.; Chakkera, H. A.; Katariya, N. N.; Khamash, H.; Moss, A.; Salomon, D. R.; Reddy, K. S.
Article Title: Transplanting Kidneys from Deceased Donors With Severe Acute Kidney Injury
Abstract: Our aim was to determine outcomes with transplanting kidneys from deceased donors with acute kidney injury, defined as a donor with terminal serum creatinine >/=2.0 mg/dL, or a donor requiring acute renal replacement therapy. We included all patients who received deceased donor kidney transplant from June 2004 to October 2013. There were 162 AKI donor transplant recipients (21% of deceased donor transplants): 139 in the standard criteria donor (SCD) and 23 in the expanded criteria donor (ECD) cohort. 71% of the AKI donors had stage 3 (severe AKI), based on acute kidney injury network (AKIN) staging. Protocol biopsies were done at 1, 4, and 12 months posttransplant. One and four month formalin-fixed paraffin embedded (FFPE) biopsies from 48 patients (24 AKI donors, 24 non-AKI) underwent global gene expression profiling using DNA microarrays (96 arrays). DGF was more common in the AKI group but eGFR, graft survival at 1 year and proportion with IF/TA>2 at 1 year were similar for the two groups. At 1 month, there were 898 differentially expressed genes in the AKI group (p-value 0.005; FDR 10%), but by 4 months there were no differences. Transplanting selected kidneys from deceased donors with AKI is safe and has excellent outcomes.
Journal Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume: 15
Issue: 8
ISSN: 1600-6143; 1600-6135
Publisher: The American Society of Transplantation and the American Society of Transplant Surgeons  
Journal Place: United States
Date Published: 2015
Start Page: 2143
End Page: 2151
Language: eng
DOI/URL:

10.1111/ajt.13260
Notes: CI: (c) Copyright 2015; JID: 100968638; CIN: Am J Transplant. 2015 Oct;15(10):2782. PMID: 26211425; OTO: NOTNLM; 2014/12/14 [received]; 2015/01/21 [revised]; 2015/02/05 [accepted]; 2015/03/24 [aheadofprint]; ppublish
LUC Authors
  1. Ramesh Batra
    4 Batra
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