New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk Journal Article

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Authors: Lu, Y; Day, F. R.; Gustafsson, S.; Buchkovich, M. L.; Na, J.; Bataille, V.; Cousminer, D. L.; Dastani, Z.; Drong, A. W.; Esko, T; Evans, D. M.; Falchi, M.; Feitosa, M. F.; Ferreira, T.; Hedman, A. K.; Haring, R.; Hysi, P. G.; Iles, M. M.; Justice, A. E.; Kanoni, S; Lagou, V.; Li, R; Li, X; Locke, A.; Lu, C.; Magi, R.; Perry, J. R.; Pers, T. H.; Qi, Q; Sanna, M.; Schmidt, E. M.; Scott, W. R.; Shungin, D.; Teumer, A; Vinkhuyzen, A. A.; Walker, R. W.; Westra, H. J.; Zhang, M; Zhang, W; Zhao, J. H.; Zhu, Z; Afzal, U; Ahluwalia, T. S.; Bakker, S. J.; Bellis, C.; Bonnefond, A; Borodulin, K.; Buchman, A. S.; Cederholm, T.; Choh, A. C.; Choi, H. J.; Curran, J. E.; de Groot, L. C.; De Jager, P. L.; Dhonukshe-Rutten, R. A.; Enneman, A. W.; Eury, E.; Evans, D. S.; Forsen, T.; Friedrich, N.; Fumeron, F.; Garcia, M. E.; Gartner, S.; Han, B. G.; Havulinna, A. S.; Hayward, C; Hernandez, D; Hillege, H.; Ittermann, T.; Kent, J. W.; Kolcic, I; Laatikainen, T.; Lahti, J.; Mateo Leach, I.; Lee, C. G.; Lee, J. Y.; Liu, T; Liu, Y; Lobbens, S; Loh, M; Lyytikainen, L. P.; Medina-Gomez, C.; Michaelsson, K.; Nalls, M. A.; Nielson, C. M.; Oozageer, L.; Pascoe, L.; Paternoster, L; Polasek, O; Ripatti, S.; Sarzynski, M. A.; Shin, C. S.; Narancic, N. S.; Spira, D.; Srikanth, P.; Steinhagen-Thiessen, E.; Sung, Y. J.; Swart, K. M.; Taittonen, L.; Tanaka, T; Tikkanen, E.; van der Velde, N.; van Schoor, N. M.; Verweij, N; Wright, A. F.; Yu, L.; Zmuda, J. M.; Eklund, N.; Forrester, T; Grarup, N; Jackson, A. U.; Kristiansson, K.; Kuulasmaa, T.; Kuusisto, J; Lichtner, P.; Luan, J; Mahajan, A; Mannisto, S.; Palmer, C. D.; Ried, J. S.; Scott, R. A.; Stancakova, A.; Wagner, P. J.; Demirkan, A; Doring, A.; Gudnason, V; Kiel, D. P.; Kuhnel, B.; Mangino, M; McKnight, B; Menni, C; O'Connell, J. R.; Oostra, B. A.; Shuldiner, A. R.; Song, K.; Vandenput, L; van Duijn, C. M.; Vollenweider, P; White, C. C.; Boehnke, M; Boettcher, Y.; Cooper, R. S.; Forouhi, N. G.; Gieger, C; Grallert, H; Hingorani, A.; Jorgensen, T.; Jousilahti, P.; Kivimaki, M; Kumari, M; Laakso, M; Langenberg, C; Linneberg, A; Luke, A; McKenzie, C. A.; Palotie, A.; Pedersen, O; Peters, A; Strauch, K; Tayo, B. O.; Wareham, N. J.; Bennett, D. A.; Bertram, L.; Blangero, J; Bluher, M.; Bouchard, C; Campbell, H; Cho, N. H.; Cummings, S. R.; Czerwinski, S. A.; Demuth, I.; Eckardt, R.; Eriksson, J. G.; Ferrucci, L; Franco, O. H.; Froguel, P; Gansevoort, R. T.; Hansen, T; Harris, T. B.; Hastie, N; Heliovaara, M.; Hofman, A; Jordan, J. M.; Jula, A.; Kahonen, M.; Kajantie, E.; Knekt, P. B.; Koskinen, S.; Kovacs, P; Lehtimaki, T.; Lind, L; Orwoll, E. S.; Osmond, C.; Perola, M; Perusse, L.; Raitakari, O. T.; Rankinen, T; Rao, D. C.; Rice, T. K.; Rivadeneira, F; Rudan, I; Salomaa, V; Sorensen, T. I.; Stumvoll, M; Tonjes, A.; Towne, B.; Tranah, G. J.; Tremblay, A.; Uitterlinden, A. G.; van der Harst, P; Vartiainen, E.; Viikari, J. S.; Vitart, V; Vohl, M. C.; Volzke, H.; Walker, M.; Wallaschofski, H.; Wild, S; Wilson, J. F.; Yengo, L; Bishop, D. T.; Borecki, I. B.; Chambers, J. C.; Cupples, L. A.; Dehghan, A; Deloukas, P; Fatemifar, G.; Fox, C; Furey, T. S.; Franke, L.; Han, J; Hunter, D. J.; Karjalainen, J.; Karpe, F.; Kaplan, R. C.; Kooner, J. S.; McCarthy, M. I.; Murabito, J. M.; Morris, A. P.; Bishop, J. A.; North, K. E.; Ohlsson, C; Ong, K. K.; Prokopenko, I; Richards, J. B.; Schadt, E. E.; Spector, T. D.; Widen, E.; Willer, C. J.; Yang, J; Ingelsson, E; Mohlke, K. L.; Hirschhorn, J. N.; Pospisilik, J. A.; Zillikens, M. C.; Lindgren, C.; Kilpelainen, T. O.; Loos, R. J.
Article Title: New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Abstract: To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Journal Title: Nature communications
Volume: 7
ISSN: 2041-1723; 2041-1723
Publisher: Unknown  
Journal Place: England
Date Published: 2016
Start Page: 10495
Language: eng
DOI/URL:

10.1038/ncomms10495
Notes: LR: 20160413; GR: 10589/Cancer Research UK/United Kingdom; GR: IK2 CX000729/CX/CSRD VA/United States; GR: K01 AR062655/AR/NIAMS NIH HHS/United States; GR: K01 HL129892/HL/NHLBI NIH HHS/United States; GR: MC_U106179471/Medical Research Council/United Kingdom; GR: MC_U106179472/Medical Research Council/United Kingdom; GR: MC_UU_12015/1/Medical Research Council/United Kingdom; GR: MC_UU_12015/2/Medical Research Council/United Kingdom; GR: R01 DK072193/DK/NIDDK NIH HHS/United States; JID: 101528555; OID: NLM: PMC4740398; 2015/06/15 [received]; 2015/12/16 [accepted]; epublish