Azithromycin use and outcomes in severe sepsis patients with and without pneumonia Journal Article


Authors: Afshar, M; Foster, C. L.; Layden, J. E.; Burnham, E. L.
Article Title: Azithromycin use and outcomes in severe sepsis patients with and without pneumonia
Abstract: PURPOSE: Studies investigating the association between macrolides and outcomes in both pulmonary and nonpulmonary critically ill patients are limited. We aimed to examine the association between azithromycin use and clinical outcomes in severe sepsis patients with and without pneumonia receiving mechanical ventilation. MATERIALS AND METHODS: A retrospective cohort of 105 patients admitted to an adult intensive care unit (ICU) with severe sepsis in an urban university hospital were included in the study. Multivariable linear regression was performed to assess the relationship between azithromycin use and the following outcomes: 28-day ICU-free days and 28-day ventilator-free days. RESULTS: In univariate analysis, patients receiving azithromycin had nearly 6 more ICU-free days on average than did patients not receiving azithromycin (P = .005). The increased ICU-free days remained in multivariable analysis adjusting for age, sex, race, ICU type, and presence of shock (P = .005). In stratified analysis examining the association of azithromycin use in severe sepsis patients without pneumonia (n = 74), the results were similar to the full cohort. CONCLUSION: Azithromycin was associated with more ICU-free days in severe sepsis patients with and without pneumonia. Further investigations are warranted to better elicit the association of macrolide use on clinical outcomes in severe sepsis patients, especially those without pneumonia.
Journal Title: Journal of critical care
Volume: 32
ISSN: 1557-8615; 0883-9441
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2016
Start Page: 120
End Page: 125
Language: eng
DOI/URL:
Notes: LR: 20160301; CI: Copyright (c) 2015; GR: R24 AA019661/AA/NIAAA NIH HHS/United States; GR: UL1 TR001082/TR/NCATS NIH HHS/United States; JID: 8610642; NIHMS746785; OID: NLM: NIHMS746785 [Available on 04/01/17]; OID: NLM: PMC4769933 [Available on 04/01/17]; OTO: NOTNLM; PMCR: 2017/04/01 00:00; 2015/09/03 [received]; 2015/11/20 [revised]; 2015/12/16 [accepted]; 2015/12/21 [aheadofprint]; ppublish
LUC Authors
  1. Jennifer Layden
    25 Layden
  2. Majid Afshar
    65 Afshar
Related LUC Article