Development of CD27+ marginal zone B cells requires GALT Journal Article

Authors: Yeramilli, V. A.; Knight, K. L.
Article Title: Development of CD27+ marginal zone B cells requires GALT
Abstract: In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27(+) CD23(-). In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23(+) follicular (FO) B cells and almost no CD27(+) MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.
Journal Title: European journal of immunology
Volume: 43
Issue: 6
ISSN: 1521-4141; 0014-2980
Publisher: WILEY-VCH Verlag GmbH Co. KGaA, Weinheim  
Journal Place: Germany
Date Published: 2013
Start Page: 1484
End Page: 1488
Language: eng
Notes: LR: 20141116; CI: (c) 2013; GR: AI068390/AI/NIAID NIH HHS/United States; GR: AI50260/AI/NIAID NIH HHS/United States; GR: R01 AI050260/AI/NIAID NIH HHS/United States; GR: R01 AI068390/AI/NIAID NIH HHS/United States; JID: 1273201; 0 (Antigens, CD27); 0 (Receptors, IgE); NIHMS502298; OID: NLM: NIHMS502298; OID: NLM: PMC3757504; 2012/11/27 [received]; 2013/01/31 [revised]; 2013/03/01 [accepted]; 2013/04/19 [aheadofprint]; ppublish