A US Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile Associated Diarrheal Isolates and their Susceptibility to Fidaxomicin Journal Article

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Authors: Snydman, D. R.; McDermott, L. A.; Jacobus, N. V.; Thorpe, C; Stone, S.; Jenkins, S. G.; Goldstein, E. J.; Patel, R; Forbes, B. A.; Mirrett, S.; Johnson, S; Gerding, D. N.
Article Title: A US Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile Associated Diarrheal Isolates and their Susceptibility to Fidaxomicin
Abstract: BACKGROUND: In 2011 a surveillance study for the susceptibility to fidaxomicin and epidemiology of C. difficile isolates in the USA was undertaken in 7 geographically dispersed medical centers. This report encompasses baseline surveillance for 2011-2012 on 925 isolates. METHODS: A convenience sample of C. difficile isolates or toxin positive stools from patients were referred to a central laboratory. Antimicrobial susceptibility was determined by agar dilution (CLSI M11- A8). CLSI, FDA or EUCAST breakpoints were applied where applicable. Toxin gene profiles were characterized by multiplex PCR on each isolate. A random sample of 322 strains, stratified by institution, underwent restriction endonuclease analysis (REA). RESULTS: Fidaxomicin MIC90 was 0.5 mug/ml for all isolates regardless of REA type or toxin gene profile, and all isolates were inhibited at
Journal Title: Antimicrobial Agents and Chemotherapy
Volume: 59
Issue: 10
ISSN: 1098-6596; 0066-4804
Publisher: Unknown  
Date Published: 2015
Start Page: 6437
End Page: 6443