Focal adhesion signaling in heart failure Journal Article

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Author: Samarel, A. M.
Article Title: Focal adhesion signaling in heart failure
Abstract: In this brief review, recent evidence is presented to indicate a role for specific components of the cardiomyocyte costamere (and its related structure the focal adhesion complex of cultured cardiomyocytes) in initiating and sustaining the aberrant signal transduction that contributes to myocardial remodeling and the progression to heart failure (HF). Special attention is devoted to the focal adhesion kinase family of nonreceptor protein tyrosine kinases in bidirectional signal transduction during cardiac remodeling and HF progression. Finally, some speculations and directions for future study are provided for this rapidly developing field of research.
Journal Title: Pflugers Archiv : European journal of physiology
Volume: 466
Issue: 6
ISSN: 1432-2013; 0031-6768
Publisher: Unknown  
Journal Place: Germany
Date Published: 2014
Start Page: 1101
End Page: 1111
Language: eng
DOI/URL:

10.1007/s00424-014-1456-8
Notes: LR: 20150601; GR: 2P01 HL062426/HL/NHLBI NIH HHS/United States; GR: P01 HL062426/HL/NHLBI NIH HHS/United States; JID: 0154720; EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases); NIHMS565010; OID: NLM: NIHMS565010; OID: NLM: PMC4037338; 2013/12/26 [received]; 2014/01/19 [accepted]; 2014/01/15 [revised]; 2014/02/12 [aheadofprint]; ppublish