Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series Journal Article

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Authors: Sadayappan, S; de Tombe, P. P.
Article Title: Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series
Abstract: Cardiac myosin binding protein-C (cMyBP-C) is a cardiac-specific thick filament assembly, accessory, and regulatory protein. Physiologically, it is a key regulator of cardiac contractility. With more than 200 mutations in the cMyBP-C gene directly linked to the development of cardiomyopathy and heart failure, cMyBP-C clearly plays a critical role in heart function. At baseline, cMyBP-C is highly phosphorylated, a condition required for normal cardiac function. However, the level of cMyBP-C phosphorylation is significantly decreased during heart failure, indicating that the level of cMyBP-C phosphorylation is directly linked to signaling and cardiac function. Early studies indicated that cMyBP-C interacts with myosin and titin, whereas studies now show that it also interacts with thin filament proteins. However, the exact role(s) of cMyBP-C in the heart remain(s) to be elucidated. As such, we invited experts in the field of cardiac muscle to identify and address key issues related to cMyBP-C by contributing a mini review on such topics as structure, function, regulation, cardiomyopathy, proteolysis, and gene therapy. Starting from this issue, Pflugers Archiv European Journal of Physiology will publish two invited mini review articles each month to discuss the most recent advances in the study of cMyBP-C.
Journal Title: Pflugers Archiv : European journal of physiology
Volume: 466
Issue: 2
ISSN: 1432-2013; 0031-6768
Publisher: Unknown  
Journal Place: Germany
Date Published: 2014
Start Page: 195
End Page: 200
Language: eng
DOI/URL:

10.1007/s00424-013-1396-8
Notes: GR: HL101297/HL/NHLBI NIH HHS/United States; GR: HL62426/HL/NHLBI NIH HHS/United States; GR: HL75494/HL/NHLBI NIH HHS/United States; GR: K02 HL114749/HL/NHLBI NIH HHS/United States; GR: K02HL114749/HL/NHLBI NIH HHS/United States; GR: P01 HL062426/HL/NHLBI NIH HHS/United States; GR: P30 HL101297/HL/NHLBI NIH HHS/United States; GR: R01 HL075494/HL/NHLBI NIH HHS/United States; GR: R01 HL105826/HL/NHLBI NIH HHS/United States; GR: R01HL105826/HL/NHLBI NIH HHS/United States; JID: 0154720; NIHMS538701; OID: NLM: NIHMS538701 [Available on 02/01/15]; OID: NLM: PMC3946865 [Available on 02/01/15]; PMCR: 2015/02/01 00:00; 2013/10/21 [received]; 2013/10/21 [accepted]; 2013/11/07 [aheadofprint]; ppublish