Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation Journal Article

Authors: Eby, J. M.; Kang, H. K.; Klarquist, J.; Chatterjee, S; Mosenson, J. A.; Nishimura, M. I.; Garrett-Mayer, E; Longley, B. J.; Engelhard, V. H.; Mehrotra, S; Le Poole, I. C.
Article Title: Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation
Abstract: To generate a mouse model of spontaneous epidermal depigmentation, parental h3TA2 mice, expressing both a human-derived, tyrosinase-reactive T-cell receptor on T cells and the matching HLA-A2 transgene, were crossed to keratin 14-promoter driven, stem cell factor transgenic (K14-SCF) mice with intra-epidermal melanocytes. In resulting Vitesse mice, spontaneous skin depigmentation precedes symmetrical and sharply demarcated patches of graying hair. Whereas the SCF transgene alone dictates a greater retinoic acid receptor-related orphan receptor gamma (RORgammat)(+) T-cell compartment, these cells displayed markedly increased IL-17 expression within Vitesse mice. Similar to patient skin, regulatory T cells were less abundant compared with K14-SCF mice, with the exception of gradually appearing patches of repigmenting skin. The subtle repigmentation observed likely reflects resilient melanocytes that coexist with skin-infiltrating, melanocyte-reactive T cells. Similar repigmenting lesions were found in a different TCR transgenic model of vitiligo developed on an SCF transgenic background, supporting a role for SCF in repigmentation.
Journal Title: Pigment cell melanoma research
Volume: 27
Issue: 6
ISSN: 1755-148X; 1755-1471
Publisher: Wiley Periodicals, Inc  
Journal Place: England
Date Published: 2014
Start Page: 1075
End Page: 1085
Language: eng
Notes: LR: 20150805; CI: (c) 2014; GR: AI068836/AI/NIAID NIH HHS/United States; GR: AR057643-03/AR/NIAMS NIH HHS/United States; GR: P01CA154778/CA/NCI NIH HHS/United States; GR: R01 AR057643/AR/NIAMS NIH HHS/United States; GR: R21 AR056524/AR/NIAMS NIH HHS/United States; JID: 101318927; 0 (Epitopes); 0 (Interleukin-17); 0 (Receptors, Antigen, T-Cell); 0 (Stem Cell Factor); EC (Monophenol Monooxygenase); NIHMS694791; OID: NLM: NIHMS694791; OID: NLM: PMC4470702; OTO: NOTNLM; 2014/04/11 [received]; 2014/06/13 [accepted]; 2014/07/21 [aheadofprint]; ppublish