A primer on clinical trial design Journal Article

Authors: Ellimoottil, C; Vijan, S.; Flanigan, R.C.
Article Title: A primer on clinical trial design
Abstract: A well-designed and executed clinical trial is the gold standard of evidence-based medicine. It is important for readers to understand the rationale for the study design, identify common pitfalls, and scrutinize limitations. Herein, we present a brief overview of types of designs used for clinical trials and discuss the use of appropriate end points, the selection of study participants, randomization, sample size calculation, blinding, and analysis of data. Finally, we emphasize the importance of accurate and transparent reporting. Our goal is to provide a primer for practicing urologists to enhance their understanding of the clinical trial literature.
Journal Title: Urologic oncology
Volume: 33
Issue: 3
ISSN: 1873-2496; 1078-1439
Publisher: Elsevier Inc  
Date Published: 2015
Start Page: 116
End Page: 121
Language: ENG
Notes: LR: 20150128; CI: Published by Elsevier Inc.; JID: 9805460; OTO: NOTNLM; 2014/09/04 [received]; 2014/12/15 [revised]; 2014/12/17 [accepted]; aheadofprint