A retrospective study evaluating the use of Permacol surgical implant in incisional and ventral hernia repair Journal Article

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Authors: Chand, B; Indeck, M.; Needleman, B.; Finnegan, M.; Van Sickle, K. R.; Ystgaard, B.; Gossetti, F.; Pullan, R. D.; Giordano, P.; McKinley, A.
Article Title: A retrospective study evaluating the use of Permacol surgical implant in incisional and ventral hernia repair
Abstract: BACKGROUND: The outcome of incisional and ventral hernia repair depends on surgical technique, patient, and material. Permacol surgical implant (crosslinked porcine collagen) has been used for over a decade; however, there are few data on outcomes. This study is the largest retrospective multinational study to date to evaluate outcomes with Permacol surgical implant in the repair of incisional and ventral hernias. METHODS: Data were collected retrospectively on 343 patients treated for 213 incisional and 130 ventral hernias. Data evaluated included patient demographics, wound classification, surgical technique, morbidity, and recurrence rates. RESULTS: Median follow-up time was 649 days (max: 2857), median age 57 years (range 23-91), and BMI 32 kg/m(2) (range 17.6-77.8). Two or more comorbidities were present in 70% of patients. Open surgery was performed in 220 (64%) patients. Permacol surgical implant was used as an underlay (250), sublay (39), onlay (37), or inlay (17). Surgical techniques included component separation (89; 25.9%), modified Stoppa technique (197; 57.4%), and Rives-Stoppa (17; 5.0%). CDC Surgical Wound Classification was Class I (190), Class II (103), Class III (28), and Class IV (22). Complications were seen in 40.5% (139) of the patients, with seroma (19%) and wound infection (15%) as the most common. Mesh removal occurred in 1 (0.3%) patient. Kaplan-Meier analysis demonstrated that the probabilities for hernia recurrence at one, two, and three years were 5.8%, 16.6%, and 31.0%, respectively. CONCLUSIONS: Permacol surgical implant was shown to be safe with relatively low rates of hernia recurrence. CLINICAL TRIAL REGISTRATION NUMBER: NCT01214252 (http://www.clinicaltrials.gov).
Journal Title: International journal of surgery (London, England)
Volume: 12
Issue: 4
ISSN: 1743-9159; 1743-9159
Publisher: Elsevier Inc  
Journal Place: England
Date Published: 2014
Start Page: 296
End Page: 303
Language: eng
DOI/URL:

10.1016/j.ijsu.2014.01.025
Notes: CI: Copyright (c) 2014; ClinicalTrials.gov/NCT01214252; JID: 101228232; 0 (Biocompatible Materials); 0 (Permacol); 9007-34-5 (Collagen); OTO: NOTNLM; 2013/07/22 [received]; 2014/01/21 [accepted]; 2014/02/05 [aheadofprint]; ppublish