Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation Journal Article

Authors: Boccardi, M.; Bocchetta, M; Ganzola, R.; Robitaille, N.; Redolfi, A.; Duchesne, S.; Jack, C. R., Jr; Frisoni, G. B.; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative
Article Title: Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation
Abstract: BACKGROUND: Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. METHODS: One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. RESULTS: Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. CONCLUSIONS: Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol.
Journal Title: Alzheimer's dementia : the journal of the Alzheimer's Association
Volume: 11
Issue: 2
ISSN: 1552-5279; 1552-5260
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2015
Start Page: 184
End Page: 194
Language: eng
Notes: CI: Copyright (c) 2015; GR: K01 AG030514/AG/NIA NIH HHS/United States; GR: P30 AG010129/AG/NIA NIH HHS/United States; JID: 101231978; OTO: NOTNLM; 2013/05/21 [aheadofprint]; ppublish