Anaplastic large cell lymphoma involving the urinary bladder: a case report and review of the literature Journal Article

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Authors: Chen, H; Li, Y; Nand, S; Quek, M. L.; Kini, A. R.; Barkan, G. A.
Article Title: Anaplastic large cell lymphoma involving the urinary bladder: a case report and review of the literature
Abstract: T cell-derived malignant lymphoma is rarely detected as a bladder neoplasm. A literature review for anaplastic large cell lymphoma (ALCL) involving urinary bladder reveals only seven previously reported cases. Here, we report a case of a 59-year-old HIV-negative man with ALK-positive ALCL. He presented an unusual clinical course with initial consideration of adult onset Still's Disease (AOSD) due to his negative results searching for malignancy and infectious diseases. He rapidly developed macrophage activation (hemophagocytic) syndrome and experienced an unusual rapid disease progression and died in 39 days after onset of symptoms. Compared to previously reported cases, the current case of ALK-1-positive ALCL is a rare case with an unusual presentation. From this case, we learned that ALCL is one malignancy that should be considered and screened in patients with suspected AOSD. Also, T-cell lymphoma associated hemophagocytic syndrome should be considered in a patient with sustained corticosteroid-resistant spike fever, high serum ferritin, and rapid exacerbation of the disease course.
Journal Title: Diagnostic cytopathology
Volume: 43
Issue: 1
ISSN: 1097-0339; 1097-0339
Publisher: Unknown  
Journal Place: United States
Date Published: 2015
Start Page: 60
End Page: 65
Language: eng
DOI/URL:

10.1002/dc.23126
Notes: CI: (c) 2014; JID: 8506895; EC 2.7.11.30 (ACVRL1 protein, human); EC 2.7.11.30 (Activin Receptors, Type II); OTO: NOTNLM; 2013/05/11 [received]; 2013/12/12 [revised]; 2014/01/16 [accepted]; 2014/03/13 [aheadofprint]; ppublish