Extracellular traps and macrophages: new roles for the versatile phagocyte Journal Article

Authors: Boe, D. M.; Curtis, B. J.; Chen, M. M.; Ippolito, J. A.; Kovacs, E. J.
Article Title: Extracellular traps and macrophages: new roles for the versatile phagocyte
Abstract: MPhi are multipurpose phagocytes with a large repertoire of well-characterized abilities and functions, including regulation of inflammation, wound healing, maintenance of tissue homeostasis, as well as serving as an integral component of the innate-immune defense against microbial pathogens. Working along with neutrophils and dendritic cells, the other myeloid-derived professional phagocytes, MPhi are one of the key effector cells initiating and directing the host reaction to pathogenic organisms and resolving subsequent responses once the threat has been cleared. ETs are a relatively novel strategy of host defense involving expulsion of nuclear material and embedded proteins from immune cells to immobilize and kill bacteria, fungi, and viruses. As research on ETs expands, it has begun to encompass many immune cell types in unexpected ways, including various types of MPhi, which are not only capable of generating METs in response to various stimuli, but recent preclinical data suggest that they are an important agent in clearing ETs and limiting ET-mediated inflammation and tissue damage. This review aims to summarize historical and recent findings of biologic research regarding ET formation and function and discuss the role of MPhi in ET physiology and associated pathologies.
Journal Title: Journal of leukocyte biology
Volume: 97
Issue: 6
ISSN: 1938-3673; 0741-5400
Publisher: Unknown  
Date Published: 2015
Start Page: 1023
End Page: 1035
Language: ENG
Notes: LR: 20150709; CI: (c) Society for Leukocyte Biology.; GR: F30 AA022856/AA/NIAAA NIH HHS/United States; JID: 8405628; OTO: NOTNLM; 2014/10/31 [received]; 2015/02/20 [accepted]; 2015/04/15 [aheadofprint]; ppublish