Regulation of GPCR Trafficking by Ubiquitin Journal Article

Authors: Kennedy, J. E.; Marchese, A
Article Title: Regulation of GPCR Trafficking by Ubiquitin
Abstract: G protein-coupled receptor (GPCR)-promoted signaling mediates cellular responses to a variety of stimuli involved in diverse physiological processes. In addition, GPCRs are also the largest class of target for many drugs used to treat a variety of diseases. Despite the role of GPCR signaling in health and disease, the molecular mechanisms governing GPCR signaling remain poorly understanding. Classically, GPCR signaling is tightly regulated by GPCR kinases and beta-arrestins, which act in a concerted fashion to govern GPCR desensitization and also GPCR trafficking. Ubiquitination has now emerged as an important posttranslational modification that has multiple roles, either directly or indirectly, in governing GPCR trafficking. Recent studies have revealed a mechanistic link between GPCR phosphorylation, beta-arrestins, and ubiquitination. Here, we review recent developments in our understanding of how ubiquitin regulates GPCR trafficking within the endocytic pathway.
Journal Title: Progress in molecular biology and translational science
Volume: 132
ISSN: 1878-0814; 1877-1173
Publisher: Elsevier Inc  
Journal Place: Netherlands
Date Published: 2015
Start Page: 15
End Page: 38
Language: eng
Notes: CI: (c) 2015; GR: GM106727/GM/NIGMS NIH HHS/United States; JID: 101498165; OTO: NOTNLM; 2015/03/25 [aheadofprint]; ppublish