Loss of the liver X receptor LXRalpha/beta in peripheral sensory neurons modifies energy expenditure Journal Article


Authors: Mansuy-Aubert, V; Gautron, L; Lee, S; Bookout, A. L.; Kusminski, C.; Sun, K.; Zhang, Y; Scherer, P. E.; Mangelsdorf, D. J.; Elmquist, J. K.
Article Title: Loss of the liver X receptor LXRalpha/beta in peripheral sensory neurons modifies energy expenditure
Abstract: Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRalpha/beta) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRalpha/beta in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.
Journal Title: eLife
Volume: 4
ISSN: 2050-084X; 2050-084X
Publisher: Unknown  
Journal Place: England
Date Published: 2015
Start Page: 10.7554/eLife.06667
Language: eng
DOI/URL:
Notes: LR: 20150618; GR: R01DK088423/DK/NIDDK NIH HHS/United States; GR: R01DK099110/DK/NIDDK NIH HHS/United States; GR: R01DK55758/DK/NIDDK NIH HHS/United States; GR: R37DK053301/DK/NIDDK NIH HHS/United States; GR: U19DK062434/DK/NIDDK NIH HHS/United States; GR: Howard Hughes Medical Institute/United States; JID: 101579614; OID: NLM: PMC4467361; OTO: NOTNLM; 2015/01/25 [received]; 2015/05/14 [accepted]; epublish