Sizing up models of heart failure: Proteomics from flies to humans Journal Article

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Authors: Kooij, V.; Venkatraman, V.; Tra, J.; Kirk, J. A.; Rowell, J.; Blice-Baum, A.; Cammarato, A.; Van Eyk, J. E.
Article Title: Sizing up models of heart failure: Proteomics from flies to humans
Abstract: Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.
Journal Title: Proteomics.Clinical applications
Volume: 8
Issue: 9-10
ISSN: 1862-8354; 1862-8346
Publisher: Unknown  
Journal Place: Germany
Date Published: 2014
Start Page: 653
End Page: 664
Language: eng
DOI/URL:

10.1002/prca.201300123
Notes: LR: 20150224; CI: (c) The Authors - PROTEOMICS Clinical Applications Published by Wiley-VCH Verlag GmbH Co. KGaA.; GR: F31-HL116167/HL/NHLBI NIH HHS/United States; GR: P01-HL077180/HL/NHLBI NIH HHS/United States; GR: T32 HL007227/HL/NHLBI NIH HHS/United States; JID: 101298608; OID: NLM: PMC4282793; OTO: NOTNLM; 2013/11/21 [received]; 2014/01/31 [revised]; 2014/04/03 [accepted]; 2014/06/25 [aheadofprint]; ppublish