Critical histologic appraisal of the pseudocapsule of small renal tumors Journal Article

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Authors: Wang, L; Feng, J.; Alvarez, H.; Snarskis, C.; Gupta, G; Picken, M. M.
Article Title: Critical histologic appraisal of the pseudocapsule of small renal tumors
Abstract: Small renal tumors are usually enwrapped in a pseudocapsule with well-confined borders, a feature that facilitates the performance of nephron-sparing surgeries (NSS). Our study was designed to evaluate the histologic features of the pseudocapsule of small renal tumors. One hundred seventy-eight renal tumors (/=0.2 mm) intra-pseudocapsular arteries. The EPE rate was also related to the nuclear grade (p = 0.001). Muscular differentiation, reticulin, and collagen components were present in the fibrous stroma of the pseudocapsule. Our study suggests that clear cell RCC has the thickest pseudocapsule while oncocytoma has a poorly developed pseudocapsule, but shows the least infiltrative pattern. In small RCC (/=0.2 mm) are encountered infrequently within the tumor pseudocapsule, with the highest percentage being found in chromophobe RCC and the lowest in papillary RCC.
Journal Title: Virchows Archiv : an international journal of pathology
Volume: 467
Issue: 3
ISSN: 1432-2307; 0945-6317
Publisher: Unknown  
Date Published: 2015
Start Page: 311
End Page: 317
Language: ENG
DOI/URL:

10.1007/s00428-015-1797-5
Notes: LR: 20150620; JID: 9423843; 2015/03/19 [received]; 2015/06/04 [accepted]; 2015/05/07 [revised]; 2015/06/19 [aheadofprint]; aheadofprint