Surgical Pain Control with Ropivacaine By Atomized Delivery (Spray): A Randomized Controlled Trial Journal Article

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Authors: Collins, G. G.; Gadzinski, J. A.; Fitzgerald, G. D.; Sheran, J.; Wagner, S.; Edelstein, S.; Mueller, E. R.
Article Title: Surgical Pain Control with Ropivacaine By Atomized Delivery (Spray): A Randomized Controlled Trial
Abstract: STUDY OBJECTIVE: To investigate the role of intra-operative Atomized Intraperitoneal Ropivacaine (AIR) as an adjuvant to anaesthetic agents at the time of minimally invasive pelvic surgery. DESIGN: Double blind, randomized controlled trial. DESIGN: Classification: Randomized controlled trial (Canadian Task Force classification I). SETTING: Tertiary care teaching hospital. PARTICIPANTS: Fifty-five patients who underwent laparoscopic and robotic gynecologic procedures. INTERVENTION: Patients received atomized saline or atomized ropivacaine (dose of 2mg/kg) immediately after the initiation of the pneumoperitoneum. MEASUREMENTS AND MAIN RESULTS: Visual analog pain scores and narcotic use (in morphine equivalents) were collected and recorded at 2, 4, 8, and 12 hours post-operatively. RESULTS: Fifty-five patients completed the study protocol and data collection, with 30 patients allocated to Atomized Intraperitoneal Saline (AIS) and 25 patients receiving the drug. Demographic and surgical variables did not vary between the groups with the exception of median operative duration. Post-operative VAS scores at 2, 4, 8 and 12 hours post-operative were higher in the patients allocated to AIS but failed to reach statistical significance. Narcotic use was also similar between the two groups. CONCLUSION: Intraperitoneal ropivacaine did not make a statistically significant difference in patient post-operative VAS scores, and in contrast to similar studies performed in general surgery, may not offer a benefit in women undergoing minimally invasive gynecologic procedures.
Journal Title: Journal of minimally invasive gynecology
ISSN: 1553-4669; 1553-4650
Publisher: AAGL. Published by Elsevier Inc  
Date Published: 2015
Language: ENG
DOI/URL:

S1553-4650(15)00541-5
Notes: LR: 20150805; CI: Copyright (c) 2015; JID: 101235322; 2015/04/03 [received]; 2015/07/23 [revised]; 2015/07/24 [accepted]; aheadofprint