Authors: |
Goldstein, E. J.; Johnson, S; Maziade, P. J.; McFarland, L. V.; Trick, W.; Dresser, L.; Millette, M.; Mazloum, H.; Low, D. E. |
Article Title: |
Pathway to Prevention of Nosocomial Clostridium difficile Infection |
Abstract: |
BACKGROUND: To address the significant morbidity and mortality rates associated with nosocomial Clostridium difficile-associated diarrhea (CDAD), a series of recommendations and a pathway to prevention were developed. METHODS: An expert panel of infectious disease (ID) specialists participated in a modified Delphi process with specific objectives: (1) conduct a review for CDAD and prevention; (2) develop statements based upon panel members' opinions; (3) hold a panel meeting during the 2012 IDWeek; and (4) review the final recommendations and prevention pathway prior to submission for publication. RESULTS: The panel voted on (1) antibiotic stewardship (7 of 8 panelists); (2) reduction of other potentially modifiable risk factors (variable); (3) utilization of specific probiotics to prevent C. difficile overgrowth (8/8); (4) staff education regarding CDAD preventive measures (8/8); (5) appropriate hand hygiene for everyone (7/8); (6) environmental cleaning (8/8); (7) medical equipment disinfection (7/8); (8) early detection of CDAD in symptomatic patients (7/8); (9) usage of protective clothing/gloves (8/8); (10) proper measures during outbreak (8/8); and (11) surveillance to monitor efficacy data of preventive measures (8/8). CONCLUSIONS: The panel members agreed with 11 of 17 recommendations presented. The additional recommendations by the panel were proton pump inhibitor use as a risk factor and the use of adjunctive therapy with specific probiotic, as it was approved by Health Canada for the risk reduction of CDAD in hospitalized patients. |
Journal Title: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
|
Volume: |
60 Suppl 2 |
ISSN: |
1537-6591; 1058-4838 |
Publisher: |
. Published by Oxford University Press on behalf of the Infectious Diseases Society of America
|
Journal Place: |
United States |
Date Published: |
2015 |
Start Page: |
S148 |
End Page: |
58 |
Language: |
eng |
DOI/URL: |
|
Notes: |
CI: (c) The Author 2015; JID: 9203213; OTO: NOTNLM; ppublish |