Multidisciplinary treatment of olfactory neuroblastoma: Patterns of failure and management of recurrence Journal Article

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Authors: Petruzzelli, G. J.; Howell, J. B.; Pederson, A; Origitano, T. C.; Byrne, R. W.; Munoz, L.; Emami, B; Clark, J. I.
Article Title: Multidisciplinary treatment of olfactory neuroblastoma: Patterns of failure and management of recurrence
Abstract: PURPOSE: Esthesioneuroblastoma is an uncommon malignancy of the head and neck for which there is no defined treatment protocol. The purpose of this study is to report our experience with the treatment and patterns of failure of this disease. METHODS AND MATERIALS: From 1994 to 2012, 37 previously unreported patients with esthesioneuroblastoma were evaluated, and 32 eventually treated for cure at 2 academic medical centers. All patients were staged with Kadish criteria. The mean and median follow-ups were 96.1 and 76.5months respectively (range 6-240months). RESULTS: The Kadish stage was A in 6 patients, B in 13 patients, and C in 13 patients. Four patients were initially treated with concurrent chemo-radiation therapy. Twenty-eight patients were treated with primary surgery. Two (2) underwent open medial maxillectomy and 26 underwent craniofacial resection (open - 17, endoscopic - 9). Three patients received curative surgical resection only. Seven patients failed either within the cranial axis or distantly, 6 of the 7 are dead of disease, 10-194months following initial treatment. Six patients had isolated neck recurrences, 4/6 were salvaged with neck dissection and additional chemo-radiation and remain alive 30-194months following initial treatment. Estimated overall survival rate at 10years was 78% based on Kadish and T stages. CONCLUSION: In this retrospective analysis of 32 patients, Kadish stage C and stage T3/T4 tumors were associated with worse outcome. Total radiation dose of 60Gy, margin status, patient age, were not found to have significant prognostic value.
Journal Title: American Journal of Otolaryngology
Volume: 36
Issue: 4
ISSN: 1532-818X; 0196-0709
Publisher: Unknown  
Date Published: 2015
Start Page: 547
End Page: 553
Language: ENG
DOI/URL:

10.1016/j.amjoto.2015.02.008
Notes: LR: 20150310; CI: Copyright (c) 2015; JID: 8000029; 2015/02/05 [received]; 2015/02/14 [accepted]; aheadofprint