Chronic wound repair and healing in older adults: current status and future research Journal Article

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Authors: Gould, L.; Abadir, P.; Brem, H.; Carter, M.; Conner-Kerr, T.; Davidson, J.; DiPietro, L.; Falanga, V.; Fife, C.; Gardner, S.; Grice, E.; Harmon, J.; Hazzard, W. R.; High, K. P.; Houghton, P.; Jacobson, N.; Kirsner, R. S.; Kovacs, E. J.; Margolis, D.; McFarland Horne, F.; Reed, M. J.; Sullivan, D. H.; Thom, S.; Tomic-Canic, M.; Walston, J.; Whitney, J. A.; Williams, J.; Zieman, S.; Schmader, K.
Article Title: Chronic wound repair and healing in older adults: current status and future research
Abstract: Older adults are more likely to have chronic wounds than younger people, and the effect of chronic wounds on quality of life is particularly profound in this population. Wound healing slows with age, but the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The effect of age and accompanying multimorbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables; lack of standardization in data collection; and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this article, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify research questions to guide future study of age-associated changes in chronic wound healing.
Journal Title: Journal of the American Geriatrics Society
Volume: 63
Issue: 3
ISSN: 1532-5415; 0002-8614
Publisher: by the American Geriatrics Society and the Wound Healing Society  
Journal Place: United States
Date Published: 2015
Start Page: 427
End Page: 438
Language: eng
DOI/URL:

10.1111/jgs.13332
Notes: CI: (c) 2015; JID: 7503062; OTO: NOTNLM; 2015/03/06 [aheadofprint]; ppublish