Intestine Immune Homeostasis after Alcohol and Burn Injury Journal Article

Authors: Li, X; Hammer, A. M.; Rendon, J. L.; Choudhry, M. A.
Article Title: Intestine Immune Homeostasis after Alcohol and Burn Injury
Abstract: Traumatic injury remains one of the most prevalent reasons for patients to be hospitalized. Burn injury accounts for 40,000 hospitalizations in the United States annually, resulting in a large burden on both the health and economic system and costing millions of dollars every year. The complications associated with post-burn care can quickly cause life-threatening conditions including sepsis, multiple organ dysfunction and failure. In addition, alcohol intoxication at the time of burn injury has been shown to exacerbate these problems. One of the biggest reasons for the onset of these complications is the global suppression of the host immune system and increased susceptibility to infection. It has been hypothesized that infections following burn and other traumatic injury may stem from pathogenic bacteria from within the host's gastrointestinal tract. The intestine is the major reservoir of bacteria within the host, and many studies have demonstrated perturbations of the intestinal barrier following burn injury. This article reviews the findings of these studies as they pertain to changes in the intestinal immune system following alcohol and burn injury.
Journal Title: Shock
Volume: 43
Issue: 6
ISSN: 1540-0514; 1073-2322
Publisher: Unknown  
Date Published: 2015
Start Page: 540
End Page: 548
Language: ENG
Notes: LR: 20150224; JID: 9421564; aheadofprint