An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias Journal Article

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Authors: Barretto, N. N.; Karahalios, D. S.; You, D.; Hemenway, C. S.
Article Title: An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias
Abstract: Misregulation of transcription elongation is proposed to underlie the pathobiology of MLL leukemia. AF4, AF9, and ENL, common MLL fusion partners, are found in complex with positive transcription elongation factor b (P-TEFb). AF9 and its homolog ENL directly interact with AF4 within these complexes. Previously, we designed a peptide that mimics the AF9 binding domain of AF4 and reported that MLL leukemia cell lines are inhibited by it. Extending these studies, we have modified the peptide design in order to avoid recognition by proteases. The peptide is as effective as its predecessor in vitro and enhances survival in mice bearing MLL leukemia cell lines.
Journal Title: Journal of experimental therapeutics oncology
Volume: 10
Issue: 4
ISSN: 1359-4117; 1359-4117
Publisher: Unknown  
Journal Place: United States
Date Published: 2014
Start Page: 293
End Page: 300
Language: eng
Notes: GR: CA 098459/CA/NCI NIH HHS/United States; JID: 9604933; ppublish