A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era Journal Article

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Authors: Evens, A. M.; Helenowski, I; Ramsdale, E.; Nabhan, C.; Karmali, R; Hanson, B.; Parsons, B.; Smith, S; Larsen, A.; McKoy, J. M.; Jovanovic, B.; Gregory, S.; Gordon, L. I.; Smith, S. M.
Article Title: A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era
Abstract: We investigated a recent (January 1999 to December 2009) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (range, 60-89 years), whereas 61% had significant comorbidity, 26% were unfit, 17% had a geriatric syndrome, and 13% had loss of activities of daily living. Overall response rate to therapy was 85%, whereas incidence of bleomycin lung toxicity was 32% (with associated mortality rate, 25%). With 66-month median follow-up, 2-year and 5-year overall survival were 73% and 58%, respectively (advanced-stage, 63% and 46%, respectively). Most International Prognostic Score factors were not prognostic on univariate analyses, whereas Cox multivariate regression identified 2 risk factors associated with inferior overall survival: (1) age more than 70 years (2.24; 95% CI, 1.16-4.33, P = .02) and (2) loss of activities of daily living (2.71; 95% CI, 1.07-6.84, P = .04). Furthermore, a novel survival model based on number of these risk factors (0, 1, or 2) showed differential 2-year OS of 83%, 70%, and 13%, respectively (P .0001) and 5-year OS of 73%, 51%, and 0%, respectively (P .0001).
Journal Title: Blood
Volume: 119
Issue: 3
ISSN: 1528-0020; 0006-4971
Publisher: American Society of Hematology  
Journal Place: United States
Date Published: 2012
Start Page: 692
End Page: 695
Language: eng
DOI/URL:

10.1182/blood-2011-09-378414
Notes: JID: 7603509; 2011/11/23 [aheadofprint]; ppublish