Epilepsy: new drug targets and neurostimulation Journal Article

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Author: Asconape, J. J.
Article Title: Epilepsy: new drug targets and neurostimulation
Abstract: Despite advances in the medical and surgical therapy for epilepsy, about 30% of patients do not achieve full seizure control. In the past 5 years new antiepileptic drugs have been approved for clinical use. Some of these drugs have unique, novel mechanisms of action. Overall efficacy of these agents, however, seems similar to other antiepileptic drugs. Vagus nerve stimulation is a well-established palliative therapy for medically resistant epilepsy. Neurostimulation, with newer devices and targets becoming available, is a rapidly expanding field in epileptology. Considerable development and research are still necessary before these newer techniques become the standard of care for the treatment of epilepsy.
Journal Title: Neurologic clinics
Volume: 31
Issue: 3
ISSN: 1557-9875; 0733-8619
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 785
End Page: 798
Language: eng
DOI/URL:

10.1016/j.ncl.2013.04.001
Notes: CI: Copyright (c) 2013; JID: 8219232; 0 (Anticonvulsants); OTO: NOTNLM; 2013/05/18 [aheadofprint]; ppublish