The velocity of cardiac sarcomere shortening: mechanisms and implications Journal Article

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Authors: de Tombe, P. P.; Ter Keurs, H. E.
Article Title: The velocity of cardiac sarcomere shortening: mechanisms and implications
Abstract: A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum of species. Here, we review the determinants of muscle dynamics by mechanical load and the relation between sarcomere shortening velocity and cross-bridge dynamics in rat myocardium containing a range of fast and slow myosin. Observations from molecular level to mechanics of the intact human heart suggest that cardiac actin-myosin kinetic properties are matched so as to optimize myocardial strain rate and allow for the maximum rate of hydraulic energy output observed during ejection in the whole ventricle.
Journal Title: Journal of muscle research and cell motility
Volume: 33
Issue: 6
ISSN: 1573-2657; 0142-4319
Publisher: Unknown  
Journal Place: Netherlands
Date Published: 2012
Start Page: 431
End Page: 437
Language: eng
DOI/URL:

10.1007/s10974-012-9310-0
Notes: GR: HL52322/HL/NHLBI NIH HHS/United States; GR: HL58860/HL/NHLBI NIH HHS/United States; GR: HL62426/HL/NHLBI NIH HHS/United States; GR: HL66140/HL/NHLBI NIH HHS/United States; GR: HL75494/HL/NHLBI NIH HHS/United States; GR: P01 HL062426/HL/NHLBI NIH HHS/United States; GR: R01 HL052322/HL/NHLBI NIH HHS/United States; GR: R01 HL075494/HL/NHLBI NIH HHS/United States; GR: Canadian Institutes of Health Research/Canada; JID: 8006298; NIHMS438990; OID: NLM: NIHMS438990; OID: NLM: PMC3568939; 2012/05/03 [received]; 2012/06/11 [accepted]; 2012/06/30 [aheadofprint]; ppublish