Novel role of Cdc42 and RalA GTPases in TNF-alpha mediated secretion of CCL2 Journal Article

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Authors: Langert, K. A.; Pervan, C. L.; Stubbs, E. B., Jr
Article Title: Novel role of Cdc42 and RalA GTPases in TNF-alpha mediated secretion of CCL2
Abstract: Transendothelial migration of autoreactive leukocytes into peripheral nerves is an early pathological hallmark of acute inflammatory demyelinating polyneuropathy (AIDP), a North American and European variant of Guillain-Barre Syndrome. Whereas the clinical management of AIDP is currently limited to non-selective immune modulating therapies, recent experimental studies support selective targeting of leukocyte trafficking as a promising alternative therapeutic strategy. Here, using a combination of targeted siRNA knockdown and pharmacological inhibitors, we report a novel role of both Cdc42 and RalA GTPases in facilitating TNF-alpha mediated CCL2 trafficking and release from immortalized rat peripheral nerve microvascular endoneurial endothelial cells. These findings raise interest in Cdc42 and RalA GTPases as potential therapeutic targets for the management of autoimmune inflammatory peripheral nerve disease.
Journal Title: Small GTPases
Volume: 5
ISSN: 2154-1256; 2154-1248
Publisher: Unknown  
Date Published: 2014
Language: ENG
DOI/URL:

29260
Notes: JID: 101530974; OTO: NOTNLM; aheadofprint; SO: Small GTPases. 2014 Jun 9;5.