The tumor microenvironment Journal Article

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Authors: Weber, C. E.; Kuo, P. C.
Article Title: The tumor microenvironment
Abstract: The concept of the tumor microenvironment, developed from Paget's "seed and soil" theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined. We will show that there are a multitude of complex interactions and a host of molecules involved in tumorogenesis and metastasis. We will further illustrate this notion with examples from the tumor microenvironment of breast cancer. Lastly, we conclude with thoughts about how this will influence the surgical field with examples of therapeutic agents already in use that target aspects of this microenvironment. Copyright 2011 Elsevier Ltd. All rights reserved.
Journal Title: Surgical oncology
Volume: 21
Issue: 3
ISSN: 0960-7404
Publisher: Unknown  
Journal Place: Netherlands
Date Published: 2012
Start Page: 172
End Page: 177
Language: English
DOI/URL:

http://hn9yf5lh6v.search.serialssolutions.com/?url_ver=Z39.88-2004=info:ofi/fmt:kev:mtx:journal=info:sid/Ovid:medl=article=info:doi/10.1016%2Fj.suronc.2011.09.001=info:pmid/21963199=0960-7404=21=3=172=172-7=2012=Surgical+Oncology=The+tumor+microenvironment.=Weber

http://dx.doi.org/10.1016/j.suronc.2011.09.001
Notes: ID: 12650; Status: MEDLINE; [Review]; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: byv, 9208188