Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury Journal Article


Authors: Vin, A. P.; Hu, H.; Zhai, Y.; Von Zee, C. L.; Logeman, A.; Stubbs, E. B., Jr; Perlman, J. I.; Bu, P
Article Title: Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury
Abstract: The purpose of the present study was to investigate whether systemically administered resveratrol can protect against acute retinal ischemic reperfusion injury. Two groups of adult male Sprague Dawley rats (n = 6 per group) were used for this study. Resveratrol (30 mg/kg) or an equal volume of vehicle (30% Solutol HS 15 in 0.9% saline) was administered daily for 5 days via intraperitoneal injection. On the third day of treatment, retinal ischemic injury was induced by elevation of intraocular pressure for 45 min. Prior to resveratrol administration and one-week following ischemic insult, retinal function was measured by scotopic electroretinography (ERG). Retinas were harvested and morphologically analyzed one week after ischemic insult. ERG a- and b-wave amplitudes were significantly reduced following ischemic reperfusion injury. Resveratrol treatment attenuated ischemic-induced loss of retinal function. In control vehicle-treated rats, ischemic reperfusion injury elicited marked thinning of inner retinal layers. Resveratrol prophylactic treatment reduced ischemia-mediated thinning of the whole retina and in particular the inner retinal layers. Therefore, resveratrol may have therapeutic value for the management of retinal ischemic disorders.
Journal Title: Experimental eye research
Volume: 108
ISSN: 1096-0007; 0014-4835
Publisher: Elsevier Inc  
Journal Place: England
Date Published: 2013
Start Page: 72
End Page: 75
Language: eng
DOI/URL:
Notes: ID: 13094; CI: Copyright (c) 2013; JID: 0370707; 0 (Neuroprotective Agents); 0 (Stilbenes); 501-36-0 (resveratrol); 2012/09/13 [received]; 2012/11/26 [revised]; 2012/11/28 [accepted]; 2012/12/31 [aheadofprint]; ppublish
LUC Authors
  1. Evan Benjamin Stubbs
    10 Stubbs
  2. Ping Bu
    9 Bu
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