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Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury Journal Article
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| Authors: | Vin, A. P.; Hu, H.; Zhai, Y.; Von Zee, C. L.; Logeman, A.; Stubbs, E. B., Jr; Perlman, J. I.; Bu, P |
| Article Title: | Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury |
| Abstract: | The purpose of the present study was to investigate whether systemically administered resveratrol can protect against acute retinal ischemic reperfusion injury. Two groups of adult male Sprague Dawley rats (n = 6 per group) were used for this study. Resveratrol (30 mg/kg) or an equal volume of vehicle (30% Solutol HS 15 in 0.9% saline) was administered daily for 5 days via intraperitoneal injection. On the third day of treatment, retinal ischemic injury was induced by elevation of intraocular pressure for 45 min. Prior to resveratrol administration and one-week following ischemic insult, retinal function was measured by scotopic electroretinography (ERG). Retinas were harvested and morphologically analyzed one week after ischemic insult. ERG a- and b-wave amplitudes were significantly reduced following ischemic reperfusion injury. Resveratrol treatment attenuated ischemic-induced loss of retinal function. In control vehicle-treated rats, ischemic reperfusion injury elicited marked thinning of inner retinal layers. Resveratrol prophylactic treatment reduced ischemia-mediated thinning of the whole retina and in particular the inner retinal layers. Therefore, resveratrol may have therapeutic value for the management of retinal ischemic disorders. |
| Journal Title: | Experimental eye research |
| Volume: | 108 |
| ISSN: | 1096-0007; 0014-4835 |
| Publisher: | Elsevier Inc |
| Journal Place: | England |
| Date Published: | 2013 |
| Start Page: | 72 |
| End Page: | 75 |
| Language: | eng |
| DOI/URL: | |
| Notes: | ID: 13094; CI: Copyright (c) 2013; JID: 0370707; 0 (Neuroprotective Agents); 0 (Stilbenes); 501-36-0 (resveratrol); 2012/09/13 [received]; 2012/11/26 [revised]; 2012/11/28 [accepted]; 2012/12/31 [aheadofprint]; ppublish |
