Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer. Journal Article

Authors: Speiser, J; Foreman, K.; Drinka, E.; Godellas, C; Perez, C; Salhadar, A.; Ersahin, C.; Rajan, P.
Article Title: Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer.
Abstract: Triple-negative breast cancer (TNBC) demonstrates lack of expression of hormone receptors and human epidermal growth factor receptor. However, there is no targeted therapy for TNBC. The authors analyzed 29 TNBC cases for Notch-1 and Notch-4 biomarker expression and subcellular location, Ki67 proliferation rate, and relevant clinical/survival data. Results demonstrated an unfavorable Ki67 rate in 90% of cases, Notch-1 expression in tumor and endothelial cells in 100% of cases, and Notch-4 expression in tumor cells in 73% of cases and endothelial cells in 100% of cases. Additionally, subcellular localization of Notch-1 and Notch-4 was predominantly nuclear and cytoplasmic. In conclusion, (a) the majority of TNBCs are high-grade infiltrating ductal carcinomas with high Ki67 proliferation rate and (b) both Notch-1 and Notch-4 receptors are overexpressed in tumor and vascular endothelial cells with subcellular localization different from that of hormone-positive breast cancer. Targeting Notch signaling with gamma secretase inhibitors should to be explored to further improve the survival rate of TNBC patients.
Journal Title: International Journal of Surgical Pathology
Volume: 20
Issue: 2
ISSN: 1940-2465
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 139
End Page: 145
Language: English
Notes: ID: 12468; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: d4a, 9314927; CAS Registry/EC Number/Name of Substance: 0 (Ki-67 Antigen). 0 (NOTCH1 protein, human). 0 (NOTCH4 protein, human). 0 (Proto-Oncogene Proteins). 0 (Receptor, Notch1). 0 (Receptors, Estrogen). 0 (Receptors, Notch). 0 (Receptors, Progesterone). 0 (Tumor Markers, Biological). EC 2-7-10-1 (Receptor, erbB-2).; Electronic Date of Publication: 20111113; Entry Date: 20120816