Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Journal Article


Authors: Rock, C. L.; Byers, T. E.; Colditz, G. A.; Demark-Wahnefried, W.; Ganz, P. A.; Wolin, K. Y.; Elias, A; Krontiras, H.; Liu, J; Naughton, M.; Pakiz, B.; Parker, B. A.; Sedjo, R. L.; Wyatt, H.; Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group
Article Title: Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial
Abstract: Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is a 4-year randomized clinical trial of 693 overweight/obese women aged >/=21years diagnosed with any early stage breast cancer (stages I[>/=1cm]-III) within the previous five years, designed to demonstrate the feasibility of achieving sustained weight loss and to examine the impact of weight loss on quality of life and co-morbidities, and to enable future exploration of biochemical mechanisms linking obesity to lower likelihood of disease-free survival. This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival. Participants were recruited between 2010 and 2012 at four sites, had completed initial therapies, and had a body mass index between 25 and 45kg/m(2). The intervention featured a group-based cognitive-behavioral weight loss program with telephone counseling and tailored newsletters to support initial weight loss and subsequent maintenance, with the goal of 7% weight loss at two years. This study has high potential to have a major impact on clinical management and outcomes after a breast cancer diagnosis. This trial initiates the effort to establish weight loss support for overweight or obese breast cancer survivors as a new standard of clinical care.
Journal Title: Contemporary clinical trials
Volume: 34
Issue: 2
ISSN: 1559-2030; 1551-7144
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 282
End Page: 295
Language: eng
DOI/URL:
Notes: CI: Copyright (c) 2012; GR: CA101489/CA/NCI NIH HHS/United States; GR: CA106919/CA/NCI NIH HHS/United States; GR: CA148791/CA/NCI NIH HHS/United States; GR: CA23100/CA/NCI NIH HHS/United States; GR: CA81191/CA/NCI NIH HHS/United States; GR: CA90413/CA/NCI NIH HHS/United States; GR: UL1 RR024992/RR/NCRR NIH HHS/United States; GR: UL1 RR024992/RR/NCRR NIH HHS/United States; JID: 101242342; NIHMS431205; OID: NLM: NIHMS431205 [Available on 03/01/14]; OID: NLM: PMC3593786 [Available on 03/01/14]; PMCR: 2014/03/01 00:00; 2012/10/05 [received]; 2012/12/13 [revised]; 2012/12/17 [accepted]; 2012/12/22 [aheadofprint]; ppublish