Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery Journal Article

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Authors: Rickey, L. M.; Huang, L; Rahn, D. D.; Hsu, Y.; Litman, H. J.; Mueller, E. R.
Article Title: Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery
Abstract: Objective. To determine baseline variables associated with urgency urinary incontinence (UUI) in women presenting for stress urinary incontinence (SUI) surgery. Methods. Baseline data from two randomized trials enrolling 1,252 women were analyzed: SISTEr (fascial sling versus Burch colposuspension) and TOMUS (retropubic versus transobturator midurethral sling). Demographic data, POP-Q measures, and validated measures of symptom severity and quality of life were collected. Charlson Comorbidity Index (CCI) and Patient Health Questionnaire-9 were measured in TOMUS. Multivariate models were constructed with UUI and symptom severity as outcomes. Results. Over two-thirds of subjects reported bothersome UUI at baseline. TOMUS patients with more comorbidities had higher UDI irritative scores (CCI score 0 = 39.4, CCI score 1 = 42.1, and CCI score 2+ = 51.0, P = 0.0003), and higher depression scores were associated with more severe UUI. Smoking, parity, prior incontinence surgery/treatment, prolapse stage, and incontinence episode frequency were not independently associated with UUI. Conclusions. There were no modifiable risk factors identified for patient-reported UUI in women presenting for SUI surgery. However, the direct relationships between comorbidity level, depression, and worsening of UUI/urgency symptoms may represent targets for preoperative intervention. Further research is necessary to elucidate the pathophysiologic mechanisms that explain the associations between these medical conditions and bladder function.
Journal Title: Advances in urology
Volume: 2013
ISSN: 1687-6369; 1687-6369
Publisher: Unknown  
Date Published: 2013
Start Page: 567375
Language: ENG
DOI/URL:

10.1155/2013/567375
Notes: JID: 101476240; 2013/07/18 [received]; 2013/09/12 [revised]; 2013/09/13 [accepted]; 2013/11/07 [epublish]; ppublish