Autopsy proven peripheral nervous system neurolymphomatosis despite negative bilateral sural nerve biopsy Journal Article


Authors: Ramirez-Zamora, A; Morales-Vidal, S.; Chawla, J; Biller, J
Article Title: Autopsy proven peripheral nervous system neurolymphomatosis despite negative bilateral sural nerve biopsy
Abstract: Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow-Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.
Journal Title: Frontiers in neurology
Volume: 4
ISSN: 1664-2295; 1664-2295
Publisher: Unknown  
Journal Place: Switzerland
Date Published: 2013
Start Page: 197
Language: eng
DOI/URL:
Notes: LR: 20131226; JID: 101546899; OID: NLM: PMC3854546; OTO: NOTNLM; 2013 [ecollection]; 2013/09/04 [received]; 2013/11/21 [accepted]; 2013/12/06 [epublish]; epublish
LUC Authors
  1. Jasvinder P. S. Chawla
    6 Chawla
  2. Jose Biller
    54 Biller
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