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The Association Between Glycemic Control and Clinical Outcomes After the Kidney Transplantation Journal Article
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| Authors: | Ramirez, S. C.; Maaske, J.; Kim, Y.; Neagu, V.; DeLange, S.; Mazhari, A; Gao, W; Emanuele, M. A.; Emanuele, N; Baldwin, D.; Mihailescu, D. V. |
| Article Title: | The Association Between Glycemic Control and Clinical Outcomes After the Kidney Transplantation |
| Abstract: | Objective: To analyze the relationship between glycemic control after renal transplantation and subsequent graft function and complications.Methods: We conducted a retrospective chart review of 202 consecutive patients undergoing kidney transplantation to analyze the association between peri-operative and chronic glycemic control and clinical outcomes of rejection, infection, and hospital readmission during the first year after kidney transplantation.Results: Mean in-hospital BG was 157+/-34.5 mg/dl. Mean HbA1C during the 12 months post-transplant was 6.84+/-1.46%. Fifty-four patients (27%) were treated for acute or chronic rejection, 88 (44%) for infection, and 149 (74%) were readmitted at least once within the first year after transplantation. There were no significant differences in the risks for rejection, infection or readmission across the five mean initial inpatient BG or subsequent HbA1C quintiles. In addition, there was no significant relationship between the percentage of BG that fell in the "tight control" range of 80-110 mg/dl for each patient and any of the outcomes.Conclusion: We did not find an association between glycemic control (peri-operative or chronic) with the outcomes of graft rejection, infection or hospital readmission, in the first 12 months after renal transplantation. Our results suggest that "near normal" glycemic targets are not necessary for managing hyperglycemia after renal transplantation. |
| Journal Title: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists |
| Volume: | 20 |
| Issue: | 9 |
| ISSN: | 1934-2403; 1530-891X |
| Publisher: | Unknown |
| Date Published: | 2014 |
| Start Page: | 894 |
| End Page: | 900 |
| Language: | ENG |
| DOI/URL: | |
| Notes: | JID: 9607439; ppublish |
