Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study Journal Article

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Authors: Pievani, M.; Bocchetta, M; Boccardi, M.; Cavedo, E.; Bonetti, M.; Thompson, P. M.; Frisoni, G. B.
Article Title: Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study
Abstract: We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E (APOE) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen (p 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes (p 0.05; Mann-Whitney test) and shape (p 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions (p 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD epsilon4 carriers and noncarriers in the left and right caudate (p 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.
Journal Title: Neurobiology of aging
Volume: 34
Issue: 7
ISSN: 1558-1497; 0197-4580
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2013
Start Page: 1728
End Page: 1739
Language: eng
DOI/URL:

10.1016/j.neurobiolaging.2013.01.016

10.1016/j.neurobiolaging.2013.01.016
Notes: CI: Copyright (c) 2013; GR: AG016570/AG/NIA NIH HHS/United States; GR: P20 RR020750/RR/NCRR NIH HHS/United States; GR: P41 RR13642/RR/NCRR NIH HHS/United States; GR: R01 LM05639/LM/NLM NIH HHS/United States; GR: R01 MH60374/MH/NIMH NIH HHS/United States; GR: R21 EB01651/EB/NIBIB NIH HHS/United States; GR: R21 RR019771/RR/NCRR NIH HHS/United States; JID: 8100437; 2012/09/26 [received]; 2013/01/10 [revised]; 2013/01/22 [accepted]; 2013/02/19 [aheadofprint]; ppublish