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Does glycemic variability impact mood and quality of life?. Journal Article
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| Authors: | Penckofer, S; Quinn, L; Byrn, M; Ferrans, C.; Miller, M.; Strange, P. |
| Article Title: | Does glycemic variability impact mood and quality of life?. |
| Abstract: | BACKGROUND: Diabetes is a chronic condition that significantly impacts quality of life. Poor glycemic control is associated with more diabetes complications, depression, and worse quality of life. The impact of glycemic variability on mood and quality of life has not been studied. METHODS: A descriptive exploratory design was used. Twenty-three women with type 2 diabetes wore a continuous glucose monitoring system for 72[THIN SPACE]h and completed a series of questionnaires. Measurements included (1) glycemic control shown by glycated hemoglobin and 24-h mean glucose, (2) glycemic variability shown by 24-h SD of the glucose readings, continuous overall net glycemic action (CONGA), and Fourier statistical models to generate smoothed curves to assess rate of change defined as "energy," and (3) mood (depression, anxiety, anger) and quality of life by questionnaires. RESULTS: Women with diabetes and co-morbid depression had higher anxiety, more anger, and lower quality of life than those without depression. Certain glycemic variability measures were associated with mood and quality of life. The 24-h SD of the glucose readings and the CONGA measures were significantly associated with health-related quality of life after adjusting for age and weight. Fourier models indicated that certain energy components were significantly associated with depression, trait anxiety, and overall quality of life. Finally, subjects with higher trait anxiety tended to have steeper glucose excursions. CONCLUSIONS: Data suggest that greater glycemic variability may be associated with lower quality of life and negative moods. Implications include replication of the study in a larger sample for the assessment of blood glucose fluctuations as they impact mood and quality of life. |
| Journal Title: | Diabetes Technology Therapeutics |
| Volume: | 14 |
| Issue: | 4 |
| ISSN: | 1557-8593 |
| Publisher: | Unknown |
| Journal Place: | United States |
| Date Published: | 2012 |
| Start Page: | 303 |
| End Page: | 310 |
| Language: | English |
| DOI/URL: | |
| Notes: | ID: 12454; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Comments: Comment in: Diabetes Technol Ther. 2012 Apr;14(4):301-2; PMID: 22335618; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: 100889084, d3x; Other ID: Source: NLM. PMC3317401 [Available on 04/01/13]; CAS Registry/EC Number/Name of Substance: 0 (Blood Glucose). 0 (Hemoglobin A, Glycosylated). 0 (hemoglobin A1c protein, human).; Grant Number: K23NR009240 (United States NINR NIH HHS); Electronic Date of Publication: 20120210; Entry Date: 20120709 |
