Semi-automated volumetric quantification of tumor necrosis in soft tissue sarcoma using contrast-enhanced MRI Journal Article

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Authors: Monsky, W. L.; Jin, B.; Molloy, C.; Canter, R. J.; Li, C. S.; Lin, T. C.; Borys, D; Mack, W.; Kim, I.; Buonocore, M. H.; Chaudhari, A. J.
Article Title: Semi-automated volumetric quantification of tumor necrosis in soft tissue sarcoma using contrast-enhanced MRI
Abstract: BACKGROUND: Response Evaluation Criteria in Solid Tumors (RECIST)-defined measurements are limited when evaluating soft tissue sarcoma (STS) response to therapy. Histopathological assessment of STS response requires a determination of necrosis following resection. A novel semi-automated technique for volumetric measurement of tumor necrosis, using enhanced magnetic resonance imaging (CE-MRI), is described. PATIENTS AND METHODS: Eighteen patients with STS were treated with neoadjuvant therapy and then resected. CE-MRI, obtained prior to resection, were evaluated by two observers using semi-automated segmentation. Tumor volume and percent necrosis was compared with histology and RECIST measurements. RESULTS: The median percent necrosis, determined histologically and from CE-MRI, was 71.9% and 67.8%, respectively. Accuracy of these semi-automated measurements was confirmed, being statistically similar to those obtained at histopathological assessment of the resected tumor. High Intra-class correlation co-efficients suggest good inter-observer reproducibility. Tumor necrosis did not correlate with the RECIST measurements. CONCLUSION: Semi-automated determination of tumor volume and necrosis, using CE-MRI, is suggested to be accurate and reproducible.
Journal Title: Anticancer Research
Volume: 32
Issue: 11
ISSN: 1791-7530; 0250-7005
Publisher: Unknown  
Journal Place: Greece
Date Published: 2012
Start Page: 4951
End Page: 4961
Language: eng
DOI/URL:

32/11/4951
Notes: JID: 8102988; 0 (Contrast Media); ppublish