Authors: |
Lima, B. P.; Thanh Huyen, T. T.; Basell, K.; Becher, D.; Antelmann, H.; Wolfe, A. J. |
Article Title: |
Inhibition of acetyl phosphate-dependent transcription by an acetylatable lysine on RNA polymerase. |
Abstract: |
The ability of bacteria to adapt to environmental changes has allowed these organisms to thrive in all parts of the globe. By monitoring their extracellular and intracellular environments, bacteria assure their most appropriate response for each environment. Post-translational modification of proteins is one mechanism by which cells respond to their changing environments. Here, we report that two post-translational modifications regulate transcription of the extracytoplasmic stress-responsive promoter cpxP: (i) acetyl phosphate-dependent phosphorylation of the response regulator CpxR and (ii) acetyl coenzyme A-dependent acetylation of the subunit of RNA polymerase. Together, these two post-translational modifications fine-tune cpxP transcription in response to changes in the intracellular environment. |
Journal Title: |
Journal of Biological Chemistry
|
Volume: |
287 |
Issue: |
38 |
ISSN: |
0021-9258 |
Publisher: |
Unknown
|
Journal Place: |
United States |
Date Published: |
2012 |
Start Page: |
32147 |
End Page: |
32160 |
Language: |
English |
DOI/URL: |
|
Notes: |
ID: 12654; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: hiv, 2985121r; Other ID: Source: NLM. PMC3442545; Grant Number: GM066130 (United States NIGMS NIH HHS) |