Mortality rates across 25-hydroxyvitamin D (25[OH]D) levels among adults with and without estimated glomerular filtration rate 60 ml/min/1.73 m2: the third national health and nutrition examination survey Journal Article

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Authors: Kramer, H; Sempos, C.; Cao, G; Luke, A; Shoham, D; Cooper, R; Durazo-Arvizu, R
Article Title: Mortality rates across 25-hydroxyvitamin D (25[OH]D) levels among adults with and without estimated glomerular filtration rate 60 ml/min/1.73 m2: the third national health and nutrition examination survey
Abstract: BACKGROUND: Previous studies exploring the association between 25[OH]D levels and mortality in adults with and without kidney disease utilized 25[OH]D thresholds that have recently been scrutinized by the Institute of Medicine Committee to Review Dietary References Intakes for Vitamin D and Calcium. OBJECTIVE: We explored all-cause mortality rates across the spectrum of 25[OH]D levels over an eighteen-year follow-up among adults with and without an estimated glomerular filtration rate (eGFR) /=60 ml/min/1.73 m(2). Mortality rates and rate ratios (RR) across 25[OH]D groups were calculated with Poisson regression and restricted cubic splines while adjusting for covariates. RESULTS: Prevalence of 25[OH]D levels /=60 ml/min/1.73 m(2). Mortality rates and rate ratios (RR) across 25[OH]D groups were calculated with Poisson regression and restricted cubic splines while adjusting for covariates. RESULTS: Prevalence of 25[OH]D levels /=60 ml/min/1.73 m(2). Mortality rates and rate ratios (RR) across 25[OH]D groups were calculated with Poisson regression and restricted cubic splines while adjusting for covariates. RESULTS: Prevalence of 25[OH]D levels /= 60 ml/min/1.73 m(2), 70.5% had 25[OH]D levels /= 60 ml/min/1.73 m(2), 70.5% had 25[OH]D levels /= 60 ml/min/1.73 m(2), 70.5% had 25[OH]D levels /= 60 ml/min/1.73 m(2), 70.5% had 25[OH]D levels /= 60 ml/min/1.73 m(2), 70.5% had 25[OH]D levels /= 60 ml/min/1.73 m(2) after adjustment for covariates including co-morbid conditions. Mortality rates were fairly similar across all 25[OH]D groups with levels >20 ng/ml after adjustment for all covariates. CONCLUSIONS: Regardless of presence of eGFR 60 ml/min/1.73 m(2), mortality rates across groups with 25[OH]D levels 20-40 ng/ml are similar.
Journal Title: PloS one
Volume: 7
Issue: 10
ISSN: 1932-6203; 1932-6203
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: e47458
Language: eng
DOI/URL:

10.1371/journal.pone.0047458
Notes: LR: 20131114; GR: 1R01DK90360-1A1/DK/NIDDK NIH HHS/United States; JID: 101285081; 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); OID: NLM: PMC3480387; 2012/05/09 [received]; 2012/09/17 [accepted]; 2012/10/24 [epublish]; ppublish