Metabolic syndrome and urinary stone composition: what factors matter most?. Journal Article

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Authors: Kadlec, A. O.; Greco, K.; Fridirici, Z. C.; Hart, S. T.; Vellos, T.; Turk, T. M.
Article Title: Metabolic syndrome and urinary stone composition: what factors matter most?.
Abstract: OBJECTIVE: To determine which metabolic syndrome (MetS) factors lead to differences in stone composition in a multivariate analysis. METHODS: We retrospectively reviewed medical charts of patients who had a kidney stone removed over a 5-year period (2006-2011). MetS factors (obesity [body mass index {BMI} >30], diabetes mellitus [DM], hypertension [HTN], and dyslipidemia [DLD]) were tallied in each patient. For the latter 3 factors, medical treatment for the condition was used to tag a patient with the condition. Stone composition was determined by the dominant (>50%) component. Statistical analysis was designed to determine which MetS factors were independently associated with differences in stone composition. RESULTS: Five hundred ninety kidney stones were included in the analysis. Patients with MetS had a higher prevalence of uric acid stones and lower prevalence of calcium phosphate stones. HTN and DM were independently associated with differences in composition, specifically uric acid stones (higher proportion), and calcium phosphate stones (lower proportion). Obesity was not associated with differences in composition, although a secondary analysis of morbidly obese patients showed a higher proportion of uric acid stones and a lower proportion of calcium oxalate stones. CONCLUSION: HTN and DM are the MetS factors independently associated with differences in stone composition, specifically the uric acid and calcium phosphate components. Obesity has little effect on stone composition until a very high (>40) BMI is reached. The overall effect of MetS factors on stone type is relatively small, because most stones are calcium oxalate and MetS factors have little impact on calcium oxalate frequency. Copyright 2012 Elsevier Inc. All rights reserved.
Journal Title: Urology
Volume: 80
Issue: 4
ISSN: 1527-9995; 0090-4295
Publisher: Elsevier Inc  
Journal Place: United States
Date Published: 2012
Start Page: 805
End Page: 810
Language: English
DOI/URL:

http://hn9yf5lh6v.search.serialssolutions.com/?url_ver=Z39.88-2004=info:ofi/fmt:kev:mtx:journal=info:sid/Ovid:medl=article=info:doi/10.1016%2Fj.urology.2012.05.011=info:pmid/22795374=0090-4295=80=4=805=805-10=2012=Urology=Metabolic+syndrome+and+urinary+stone+composition%3A+what+factors+matter+most%3F.=Kadlec

http://dx.doi.org/10.1016/j.urology.2012.05.011
Notes: ID: 12642; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: wsy, 0366151; Publisher Item Identifier: S0090-4295(12)00542-0